冠状动脉是白质过强度的独立风险因素吗?
Hui Jin1,2, Xue Qin1, Fanfan Zhao2
1Bengbu Medical College, Bengbu, 233030, China.
BMC neurology
|August 30, 2023
概括
冠状动脉 (CAC) 严重程度与老年人白质强度 (WMH) 量增加有关. 这表明血管疾病之间的联系超出了传统的风险因素.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 心血管疾病是全球死亡率和残疾的主要原因.
- 冠状动脉 (CAC) 量化了冠状动脉样硬化的严重程度.
- 白质过强度 (WMH) 是小血管缺血病的标志物.
研究的目的:
- 调查CAC和WMH之间的关系.
- 探索CAC在评估WMH负担中的诊断实用性.
主要方法:
- 在MRI和CT扫描上对342名WMH患者的回顾性分析.
- 使用损伤预测算法自动测量WMH体积.
- 多级混合效应线性回归以评估CAC得分和WMH体积之间的关联,调整血管风险因素.
主要成果:
- 与没有 (得分 = 0) 的人相比,患有CAC (得分>0) 的个人表现出更大的WMH体积.
- 在增加CAC得分和WMH量之间观察到显著的正相关性.
- 线性回归表明,在高CAC组中,每增加1%的CAC得分,WMH体积增加2.96%,即使在对共变量进行调整后.
结论:
- CAC的存在和严重程度与老年人的WMH体积增加有关.
- 研究结果表明,一种潜在的并发症机制将不同血管床的血管疾病联系在一起.
- 这种关联独立于传统的血管风险因素存在.
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