向CD38和LMP1的CAR-T细胞对NK/T细胞淋巴瘤表现出强大的抗瘤活性
Hongwen Li1,2, Wenting Song1,2,3, Jiazhuo Wu1,2,3
1Department of Oncology, Jianshendong Rd., The First Affiliated Hospital of Zhengzhou University, No. 1, Zhengzhou, 450052, Henan Province, China.
BMC medicine
|August 30, 2023
概括
化学抗原受体转化T (CAR-T) 细胞疗法显示出治疗自然杀手/T细胞淋巴瘤 (NKTCL) 的前景. 生成的CAR-T细胞系在体外和体内有效地消除了NKTCL细胞,表明了治疗潜力.
科学领域:
- 免疫治疗是一种免疫疗法.
- 在瘤学瘤学.
- 细胞疗法细胞疗法
背景情况:
- 自然杀手/T细胞淋巴瘤 (NKTCL) 是一种具有不良预后的侵袭性血液性恶性瘤.
- 化学抗原受体转化T (CAR-T) 细胞治疗是一种新兴的免疫治疗策略,用于血液恶性瘤.
研究的目的:
- 评估新型CAR-T细胞系对NKTCL的疗效.
- 评估CD38-CAR,LMP1-CAR和CD38-LMP1联CAR-T细胞的体外和体内抗NKTCL活性.
主要方法:
- 生成四个不同的CAR-T细胞系,针对NKTCL.
- 在体外评估CAR-T细胞对NKTCL细胞的细胞毒性.
- 在异种移植的NKTCL小鼠模型中对CAR-T细胞抗瘤作用的体内评估.
- 通过流式细胞计量检测T细胞激活标记物和细胞因子生产.
主要成果:
- 四个CAR-T细胞系都在体外有效消除了恶性NKTCL细胞.
- 卡尔-T细胞表现出依赖于标的激活,并产生炎症性细胞因子.
- 在活体中使用异种移植的NKTCL小鼠模型观察到显著的抗瘤效应.
结论:
- 开发的CD38和LMP1CAR-T细胞系对NKTCL细胞具有显著的细胞毒性.
- 这些CAR-T细胞策略在治疗NKTCL方面具有前景.
关键词:
在CART-T中,我们可以使用CAR-T.CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38免疫治疗是一种免疫疗法.在LMP1中,LMP1是LMP1.在NKTCL中,它是NKTCL.两个人一起走,Tandem.更多相关视频
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