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一种 Babesia microti 的保存蛋白质引起了对 Babesia 和 Plasmodium 感染的部分保护

Yao Wang¹, Qianqian Zhang², Wanruo Zhang¹

¹School of Biology and Basic Medical Sciences, Soochow University, No.199 Renai Road, Suzhou, 215123, People's Republic of China.

Parasites & vectors

|August 30, 2023

概括

一种Babesia微型抗原Bm8显示出作为广泛的疫苗候选人的前景. 用Bm8接种疫苗在感染巴贝菌病或杆菌的小鼠中降低了寄生虫负担,这表明潜在的跨物种保护.

科学领域:

寄生虫学的寄生虫学
免疫学免疫学免疫学
疫苗开发疫苗开发

背景情况:

由Babesia microti引起的宝贝菌病是一种动物传播疾病,目前没有疫苗.
寄生虫居住在宿主红细胞中,使治疗和预防复杂化.

研究的目的:

为了评估Bm8抗原作为潜在的疫苗候选人对抗Babesia microti和Plasmodium感染.
为了研究由Bm8.8引起的交叉保护性免疫反应.

主要方法:

通过高通量查,在B. microti中确定了Bm8作为一种保存的,高度血清活性的抗原.
产生了重组Bm8 (rBm8),并证实了它在寄生虫中的定位.
在B. microti和P. berghei感染的小鼠模型中测试了rBm8免疫性和疗效.

主要成果:

Bm8被感染小鼠的血清识别出来,表明它是一个免疫源的目标.
接种Bm8免疫的小鼠在感染B. microti或P. berghei.后显示寄生虫负载减少.
用Bm8抗菌素的被动免疫提供了对这两种寄生虫感染的部分保护.

结论:

B. microti Bm8抗原会引起一种保护性免疫反应.
Bm8显示出作为一种新的,广泛的疫苗候选人,可以对抗婴儿病和疟疾.
对基于Bm8的疫苗的进一步研究可以解决重大公共卫生挑战.

关键词:

抗原是一种抗原.贝贝西亚微型生物信息学分析保存的蛋白质是一种保存的蛋白质.疫苗疫苗疫苗疫苗

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