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Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
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抑制FOXO1产生强大的非激活的CAR T细胞来对抗固体瘤

Maude Marchais1,2, Luca Simula2, Mélanie Phayanouvong3

  • 1CNRS UMR9196, Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, Gustave Roussy, Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.

Cancer immunology research
|August 30, 2023
PubMed
概括

研究人员开发了一种新方法,通过抑制FOXO1.1,在没有活体预激活的情况下创建嵌合式抗原受体 (CAR) T细胞. 这种新型的CAR T细胞疗法增强了抗瘤功能,并显示出对固体瘤的疗效有所改善.

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