父亲的偏见吸烟和后代的DNA甲基化
Negusse Tadesse Kitaba1, Gerd Toril Mørkve Knudsen2,3, Ane Johannessen4
1Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
Clinical epigenetics
|August 30, 2023
概括
父亲预先认知吸烟与后代DNA的表观遗传变化有关,特别是影响与喘,体重和BMI相关的基因. 这些发现表明,父亲吸烟如何影响子女健康的机制跨世代.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 人类遗传学 人类遗传学
- 环境健康 环境健康
背景情况:
- 实验研究表明,父亲的暴露可以从基因上影响后代的呼吸系统健康.
- 人类研究对父亲吸烟的代际表观遗传影响是有限的.
- 这项研究调查了与父亲的怀孕前吸烟相关的后代的表观遗传标记.
研究的目的:
- 为了识别与父亲的怀孕前吸烟相关的后代的特定表观遗传标记 (DNA甲基化).
- 探索父亲在青春期开始吸烟和后代表观遗传学之间的联系.
- 检查这些表观遗传变化是否与后代的健康结果相关.
主要方法:
- 在RHINESSA队列上进行了全表观基因组关联研究 (EWAS).
- 通过使用Infinium MethylationEPIC Beadchip数组分析了DNA甲基化.
- 对后代的年龄,个人吸烟和母亲吸烟进行了统计调整.
主要成果:
- 父亲怀孕前吸烟与后代血液DNA中的两个CpG位点 (PRR5,CENPP) 的差异甲基化有关.
- 父亲在青春期吸烟 (<15岁) 与14个基因中的19个差异甲基化CpG有关.
- 这些甲基化变化与后代的喘,喘息,体重和BMI有关,并丰富了基因表达调节,炎症和先天免疫力的基因本体学途径.
结论:
- 父亲的预孕吸烟,特别是在青春期,与后代的DNA甲基化有关.
- 表观遗传机制可能解释了父亲吸烟与子女患喘,低肺功能和肥胖的风险增加之间的流行病学联系.
- 这些发现突出了父亲的生活方式通过表观遗传影响后代健康的潜力.
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