SARS-CoV-2的神经表现:复杂性,机制和相关疾病
Kritika Tyagi1, Prachi Rai1, Anuj Gautam1
1Department of Biophysics, Panjab University, Chandigarh, India.
European journal of medical research
|August 30, 2023
概括
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 可以侵入中枢神经系统 (CNS),导致各种神经系统疾病和认知能力下降. 了解这些影响对于开发有效治疗COVID-19患者至关重要.
科学领域:
- 神经学 神经学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒,包括SARS-CoV-2,与严重的呼吸系统疾病有关,并可能导致严重的健康问题.
- 导致COVID-19的病毒SARS-CoV-2可能通过嗅觉通路进入人体,利用ACE2受体进入细胞.
- 该病毒有可能突破血脑屏障 (BBB),影响中枢神经系统 (CNS),并导致神经系统并发症.
研究的目的:
- 审查SARS-CoV-2感染如何影响大脑功能.
- 讨论与SARS-CoV-2相关的中枢神经系统疾病,如中风,血栓症和脑炎.
- 详细介绍COVID-19患者大脑血管并发症所涉及的机制和途径.
主要方法:
- 审查有关SARS-CoV-2穿越BBB进入中枢神经系统的现有报告.
- 在COVID-19患者中观察到的神经并发症的分析,包括睡眠障碍,脑炎,头痛和认知障碍.
- 检查潜在的病毒进入大脑的机制,如神经向性,直接透和细胞因子风暴路径,以嗅觉叶片作为主要路径.
主要成果:
- 在大脑脊髓液 (CSF),皮质神经元和人类大脑器官中检测到SARS-CoV-2.
- COVID-19患者的神经复杂症包括头痛,认知障碍,睡眠障碍和病毒性脑炎.
- 病毒可以通过直接途径,神经向性传播或通过细胞因子风暴透到大脑.
结论:
- 感染SARS-CoV-2可能会导致神经系统并发症,包括脑血管事件和认知能力下降.
- COVID-19与中风和血栓形成等脑血管疾病有关,影响神经系统.
- 紧急的药物重新定位和新疗法开发对于管理SARS-CoV-2的神经影响至关重要.
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