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Updated: Jul 17, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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在持续释放配方的开发中整合人工神经网络和基于生理学的生物制药模型

Frederico Severino Martins1,2, Luiza Borges3, Rene Oliveira do Couto4

  • 1esqLABS GmbH, Saterland, Germany.

Biopharmaceutics & drug disposition
|August 30, 2023
PubMed
概括

基于模型的药物开发使用人工神经网络 (ANN) 和基于生理学的生物制药建模 (PBBM) 来优化甲胺HCl配方. 这种方法成功地预测了持续释放片的生物等价性,帮助了仿制药行业.

关键词:
美国的 PBBM PBBM人工智能的人工智能是人工智能.仿制药是一般的药物.建模 建模模型 建模模型虚拟的生物等价性

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