关于心脏代谢风险因素与COVID-19结果严重程度之间的联系的网络元分析
Alina Binbin Li1, Bo Yang1, Yufei Li1
1Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA.
Journal of diabetes
|August 31, 2023
概括
心脏代谢风险因素增加了COVID-19的严重程度. 脑卒中和心力衰竭分别是最高的死亡率和严重性风险. 结合心血管疾病和糖尿病是最有害的.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 心脏代谢并发症与COVID-19严重程度和死亡率的增加有关.
- 需要进一步的研究来确定COVID-19结果中最有害的心脏代谢风险因素.
研究的目的:
- 系统地评估各种心脏代谢风险因素与COVID-19结果之间的关联.
- 确定哪些特定的心脏代谢疾病在COVID-19患者中构成住院,严重程度和死亡的最大风险.
主要方法:
- 在Embase,Emcare和MEDLINE的系统文献搜索中,查找截至2021年5月19日发表的研究.
- 包括评估心脏代谢风险因素和COVID-19结果的前性和后性研究.
- 使用纽卡斯尔-太华尺度对所包含研究的质量评估.
主要成果:
- 除了超重,所有研究的心脏代谢风险因素都与COVID-19住院治疗,严重程度和死亡率的增加有关.
- 糖尿病显示了住院的最高风险 (RR 1.46),严重结局的心力衰竭 (RR 1.89) 和中风的死亡率 (RR 1.99).
- 脑血管疾病在网络元分析中影响最大 (RR 1.69);结合心血管疾病和糖尿病是最有害的 (RR 6.98).
结论:
- 心脏代谢并发症显著增加了严重的COVID-19结果的风险.
- 患有心脏代谢疾病的患者需要优先考虑COVID-19疫苗接种和治疗策略.
- 识别和管理这些风险因素对于减轻COVID-19的影响至关重要.
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