哺乳动物的胃肠道不是一个主要的额外上来源的黑激素
1Robinson Research Institute and Adelaide School of Medicine, University of Adelaide, Adelaide Health and Medical Science Building, North Terrace, Adelaide, South Australia, Australia.
Journal of pineal research
|August 31, 2023
概括
与之前的研究相反,肠道不会比松果腺产生明显更多的黑激素. 新的分析表明松果腺是黑激素的主要来源,而不是胃肠道.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 时间生物学 时间生物学
背景情况:
- 1992年的一项研究报告了大鼠十二指肠中的高黑激素水平,这导致了长期以来的信念,即肠道是主要的黑激素生产者.
- 三十年来,这种信念影响了人们对黑激素在血水平和昼夜节律中的作用的理解.
- 最初的研究结果在很大程度上没有受到质疑,直到现在.
研究的目的:
- 重新评估胃肠道对循环黑激素水平的贡献.
- 批判性地评估以前关于肠道美拉托尼生产的研究的方法和发现.
- 为了确定血黑色素的主要来源.
主要方法:
- 文献综述和现有关于松果腺和肠道中黑激素含量的研究的批判性分析.
- 检查切除术对循环中的氨酸的影响.
- 在先前的研究中评估免疫测试验证和交叉反应性问题.
主要成果:
- 松果切除术有效地从循环中去除黑激素,支持松果腺作为主要来源.
- 报告高肠道黑激素水平的研究经常使用具有显著交叉反应性的不良验证的免疫试验.
- 当代研究显示肠道黑激素含量明显低于最初报告的含量,其比例表明肠道产量很少或不存在.
结论:
- 胃肠道并不是一种主要的额外上腺黑激素的来源.
- 由于方法上的局限性,之前对肠道黑激素产生的估计被大大高估了.
- 松果腺仍然是循环中的黑色素的主要来源.
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