在三文鱼中,T细胞受体β位置的演变
Pierre Boudinot1, Samuel Novas2, Luc Jouneau1
1Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Frontiers in immunology
|August 31, 2023
概括
研究人员在彩虹鱼中特征了T细胞受体β (TRB) 位点,揭示了在鱼类中保存的双位点结构. 这为研究鱼类免疫反应和TRB剧集多样性提供了基础.
科学领域:
- 免疫遗传学 免疫遗传学
- 进行比较基因组学.
- 水生动物卫生 水生动物卫生
背景情况:
- T细胞受体 (TR) 位置对于适应性免疫至关重要,但由于基因组组装限制,它们的表征在非模型生物中具有挑战性.
- 鱼类是重要的水产养殖物种,它们具有复杂的TR位点,需要详细的注释来理解它们的免疫系统.
研究的目的:
- 在彩虹鱼 (Oncorhynchus mykiss) 中描述和注释T细胞受体β (TRB) 位点.
- 为了研究跨鱼类物种的TRB位点的结构变异和进化史.
- 为鱼类TRB loci.建立一个标准化的命名体系.
主要方法:
- 彩虹鱼的高质量基因组组合被用于TRB loci的详细注释.
- 在不同类型的鱼类中对TRB位点结构进行了比较分析.
- 生物信息工具用于序列映射和位置识别.
主要成果:
- 彩虹鱼的TRB位点在染色体19和25上得到了完整描述和注释.
- 证实了一种保存的鱼TRB位点结构,在两个染色体上具有相反方向的双组TRBV-D-J-C基因.
- 这项研究提供了关于鱼全基因组复制 (WGD) 后TRB位点的演变的见解.
结论:
- 有特征的彩虹鱼TRB位点和已建立的命名体系为鱼免疫遗传学提供了基本的资源.
- 这项工作促进了对T细胞受体谱系多样性和鱼种群免疫反应的未来研究.
- 了解TRB位点结构对于推进鱼类免疫学和健康管理方面的研究至关重要.
相关概念视频
Diversity of Antigen Receptors
630
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
630
T Cell Activation and Clonal Selection
804
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
804
Cis-regulatory Sequences
9.9K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
9.9K
Gene Duplication and Divergence
6.2K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.2K


