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在瘤和纤维化中的EMT变化中,PDL1的作用是什么?
Yun-Chao Zhang1, Yu-Ting Zhang1, Yi Wang1
1Department of Nephrology, Xi Jing Hospital, The Fourth Military Medical University, Xi'an, China.
Frontiers in immunology
|August 31, 2023
概括
编程细胞死亡配体1 (PDL1) 双向调节上皮层-介质细胞转化 (EMT),影响癌症和纤维化. 向PDL1通过调节免疫反应和疾病进展来提供治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 表皮介质转化 (EMT) 在发育,纤维化和癌症侵入性方面至关重要.
- 编程细胞死亡配体1 (PDL1) 与EMT密切相关,影响其双向调节.
- PDL1信号影响癌细胞迁移,入侵和纤维化发展.
研究的目的:
- 审查PDL1在免疫调节,生长和纤维化促进中的多方面的作用.
- 讨论PDL1在EMT相关疾病中的机制,挑战和临床观察.
- 探索向癌症和纤维化中的PDL1的治疗潜力.
主要方法:
- 关于PDL1和EMT的研究的文献综述.
- 分析涉及PDL1和EMT相关因素的监管途径.
- 对癌症和纤维化中的PDL1抑制剂的临床试验数据的检查.
主要成果:
- 在EMT期间,PDL1表达在各种瘤类型中发生动态变化.
- 通过PI3K/AKT和MAPK通路,PDL1信号促进EMT,增强癌细胞入侵.
- PDL1抑制剂在治疗癌症和通过调节纤维细胞激活和基质沉积来减少纤维化方面表现有前途.
结论:
- PDL1在促进纤维化和调节免疫反应方面发挥着双重作用,具有重要的治疗意义.
- 准PDL1为管理EMT相关疾病,包括癌症和纤维化提供了一个有希望的策略.
- 在II型EMT纤维化中,平衡纤维化调节和免疫反应调节是有效的PDL1向治疗的关键.
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