高流动性群体的尿液和血清水平第1框
Toshihiko Nakamura1, Atsushi Yoshida2, Daisuke Hatanaka1
1Department of Neonatology, Japanese Musashino Red Cross Hospital, Japan.
Practical laboratory medicine
|August 31, 2023
概括
尿路高流动性组盒子1 (HMGB-1) 的水平与新生儿的血清HMGB-1有显著的相关性. 这表明尿液HMGB-1可能是一个可行的,最少的侵入性生物标志物用于新生儿健康评估.
科学领域:
- 生物化学 生化学
- 新生儿医学 新生儿医学
- 生物标志物发现发现
背景情况:
- 高流动性组第1框 (HMGB-1) 在成人和新生儿中进行研究.
- 对不健康的新生儿来说,最少的侵入性临床检查至关重要.
研究的目的:
- 为了比较尿液高流动性组盒1 (HMGB-1) 水平与新生儿血清HMGB-1水平.
- 探索尿液HMGB-1作为一种潜在的非侵入性生物标志物.
主要方法:
- 招募了87名新生儿,从带血液和尿液中采集了样本.
- 在血清和尿液样本中测量了HMGB-1水平.
主要成果:
- 在所有新生儿尿样中检测到HMGB-1.
- 在血清和尿液HMGB-1水平之间发现了显著的正相关性 (r=0.73,p<0.001).
- 与对照组相比,胎儿新生儿窒息症的新生儿在尿液中的HMGB-1水平更高.
结论:
- 尿液分泌是HMGB-1的潜在代谢途径.
- 尿液中的HMGB-1水平显示出,在新生儿早期,它是与血清HMGB-1的可比且最小侵入性的替代品.
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