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胸头犬和非胸头犬之间选择的血液参数的差异
Sandra Kämpf1,2,3, Simone Fenk1,2, Ankie Van Cromvoirt1,2
1Red Blood Cell Research Group, Institute of Veterinary Physiology, Faculty of Vetsuisse, University of Zurich, Zürich, Switzerland.
Frontiers in veterinary science
|August 31, 2023
概括
与非胸头犬相比,胸头犬表现出明显的血液参数变化,包括改变的红细胞和压力标志物,与非胸头犬相比. 这些发现可能有助于开发客观的血液测试,以分级胸头阻塞性呼吸道综合征 (BOAS).
科学领域:
- 兽医医学 兽医医学 兽医医学
- 比较病理学比较病理学
- 动物生理学 动物生理学
背景情况:
- 脊髓头状狗具有独特的头骨解剖学,使它们易患脊髓头状阻塞性气道综合征 (BOAS).
- 博阿斯的特点是周期性呼吸暂停,呼吸阻力增加和温度调节受损.
- 目前缺乏评估BOAS严重性的客观标志物.
研究的目的:
- 为了比较头 (BC) 和非头 (NC) 狗之间选择的血液参数.
- 探索血液参数作为未来BOAS严重程度分级指标的潜力.
主要方法:
- 评估血液生物化学,完整血细胞计数和红细胞 (RBC) 指数.
- 评估红细胞水分,可变形性和间歇性缺氧的标志物 (谷氨,NO生产).
- 对代谢变化和压力的血液标记物的分析,包括血乳酸,胆固醇,甘油三和皮质醇.
主要成果:
- BC犬的网细胞数量显著增加,中光不成熟的网细胞.
- 在BC犬中观察到血NO衍生的NO/NOx和更高的体质血红蛋白平均度.
- 在BC犬中,细胞内减少的谷氨含量较低,血中乳酸盐含量较高,胆固醇和甘油三含量较低,皮质醇含量较高,乙氨基基酸含量较低,中性粒细胞与淋巴细胞的比例较高.
结论:
- 胸头类表型与狗的全身氧化和代谢变化有关.
- 鉴定的血液参数需要进一步调查,作为BOAS严重程度的客观指标.
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