药物透性:从血脑屏障到外围神经屏障
Yifei Sun1, Mahmood Zabihi1, Qi Li1
1Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487, USA.
Advanced therapeutics
|August 31, 2023
概括
本综述探讨了通过适应用于血脑屏障 (BBB) 的策略来增强通过外围神经屏障 (PNB) 的药物输送. 这种方法旨在改善神经病痛和外围神经疾病的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
背景情况:
- 对外围神经进行有效的药物输送对于局部麻醉和治疗神经病变至关重要.
- 周围神经屏障 (PNB),包括周围神经和血神经屏障 (BNB),限制药物进入轴突.
- 通过血脑屏障 (BBB) 增强药物透性的策略已经得到很好的发展,但对于PNB来说却不那么成熟.
研究的目的:
- 审查和比较BBB和PNB的结构,分子和功能特征.
- 总结现有的中枢神经系统 (CNS) 和外周神经系统 (PNS) 的药物输送策略.
- 讨论中枢神经系统药物输送策略的适应性,以改善外周神经药物输送.
主要方法:
- 文学评论比较了BBB和PNB的属性.
- 对中枢神经系统和神经系统疾病的当前药物输送策略的比较分析.
- 讨论集中在中枢神经系统的策略对外围神经药物递送的潜在应用.
主要成果:
- 确定了BBB和PNB之间的相似之处和差异.
- 强调了与中枢神经系统相比,对外围神经的药物输送策略的研究不足.
- 建议中枢神经系统的药物输送方法可以适应外围神经应用.
结论:
- 通过加强BBB的药物输送获得的知识可以为外围神经障碍的策略提供信息.
- 调整中枢神经系统药物输送技术有望提高对外围神经病变和神经病痛的治疗疗效.
- 需要进行进一步的研究来探索和验证这些适应的外围神经药物输送策略.
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