一个健康状态实用研究,以引起与肺高血压相关的社会价值观
Beenish Nafees1, Hayley M de Freitas1, Amélie Beaudet2
1Patient-Reported Outcomes, Nafees Consulting Limited, London, UK.
Patient preference and adherence
|August 31, 2023
概括
这项研究为英国的肺动脉高血压 (PAH) 和慢性血栓栓塞性肺高血压 (CTEPH) 提供了第一个社会实用值. 结果突出了疾病严重程度和治疗对与健康相关的生活质量的重大影响.
科学领域:
- 卫生经济学 卫生经济学
- 肺血管疾病 肺血管疾病
- 生活质量研究 研究 生命质量研究
背景情况:
- 肺高血压 (PH) 是一种严重的,进展性疾病,影响与健康相关的生活质量 (HRQL).
- 慢性血栓栓塞性肺高血压 (CTEPH) 是PH的一个亚组,可以通过肺内关节切除术 (PEA) 和气球肺血管造形术 (BPA) 等手术来治疗.
- 社会实用价值对健康经济评估至关重要,但在英国的特定PH和CTEPH州缺乏.
研究的目的:
- 在英国引发肺动脉高血压 (PAH) 和CTEPH的新型社会健康状态实用值.
- 根据疾病严重程度 (功能类),临床事件 (住院治疗) 和CTEPH特定的治疗程序 (PEA,BPA) 来评估公用事业.
- 为健康经济模型和政策决策提供有关PH和CTEPH管理的信息.
主要方法:
- 定义了六种健康状况:WHO-FC II,III,IV;与PH相关的住院治疗;BPA手术和恢复;PEA手术和恢复.
- 进行文献审查和专家/患者采访,以定义和验证健康状况.
- 估值的健康状况使用时间交易 (TTO) 与200名英国普通公众参与者.
主要成果:
- 平均TTO公用事业是:FC II (0.81),BPA (0.80),PEA (0.78),FC III (0.59),FC IV (0.28),以及住院治疗 (0.25).这些公用事业包括:FC II (0.81),BPA (0.80),PEA (0.78),FC III (0.59),FC IV (0.28),以及住院治疗 (0.25).
- 较差的TTO分数与功能类严重性增加相关.
- 确定了关键的CTEPH治疗程序和住院治疗的独特实用值.
结论:
- 这项研究为英国的PAH和CTEPH提供了第一个社会实用价值.
- 这些发现为对PH和CTEPH干预措施的健康经济评估提供了关键数据.
- 结果强调了PH和CTEPH对HRQL的重大负担,区分疾病严重程度和治疗影响.
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