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怀孕期间的抗生素会影响婴儿时期的鼻腔微生物群和呼吸道发病率
Céline Rüttimann1,2, Annika Nissen-Kratzert1,2, Nadja Mostacci3
1University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
ERJ open research
|August 31, 2023
概括
在第三个三个月内产前接触抗生素会影响婴儿鼻腔微生物群的多样性,并增加呼吸系统疾病的风险. 这些对呼吸系统健康的影响独立于微生物组变化而发生,并不会持续到童年.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 产前抗生素暴露对婴儿呼吸系统健康和潜在机制的影响仍然不清楚.
- 调查第三季度抗生素使用,婴儿鼻腔微生物组和呼吸系统结果之间的联系至关重要.
研究的目的:
- 确定产前抗生素暴露是否与婴儿和学龄儿童的鼻子微生物组合和呼吸道发病率有关.
- 评估鼻子微生物组是否调解产前抗生素暴露和呼吸道疾病之间的关系.
主要方法:
- 来自296名婴儿的鼻子拭子的16S rRNA基因测序.
- 通过每周采访和6年临床访问评估呼吸系统症状.
- 结构方程建模用于分析直接和间接的关联.
主要成果:
- 在产前接触过抗生素的婴儿显示鼻腔微生物群多样性减少 (香农指数p=0.006).
- 产前抗生素暴露与婴儿期呼吸系统症状的风险增加相关 (RR 1.38,p=0.032).
- 没有观察到鼻子微生物组对呼吸系统症状的调解作用.
结论:
- 产前抗生素暴露与婴儿时期鼻微生物群多样性减少有关.
- 在婴儿期与产前抗生素暴露相关的呼吸道疾病似乎独立于微生物组的改变.
- 在儿童时期没有观察到与产前抗生素暴露有关的长期呼吸道症状.
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