呼出的挥发性有机化合物与阻塞性肺部疾病的危险因素相关:系统性审查
Shahriyar Shahbazi Khamas1,2,3, Amir Hossein Alizadeh Bahmani1,2,3, Susanne J H Vijverberg1,2,3
1Department of Pulmonary Medicine, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.
ERJ open research
|August 31, 2023
概括
需要新的生物标志物来早期检测喘和COPD恶化. 本次审查确定了与风险因素相关的挥发性有机化合物 (VOC),这对于开发新的护理点呼吸测试至关重要.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 生物标志物发现发现
- 分析化学 分析化学
背景情况:
- 喘和COPD是普遍存在的呼吸道疾病,需要改进对恶化的早期检测.
- 呼出空气的非侵入性代谢学为即时诊断提供了潜力.
- 阻塞性肺部疾病的危险因素可能会混挥发性有机化合物 (VOC) 模式,模仿疾病标志物.
研究的目的:
- 系统地审查和列出与阻塞性肺部疾病风险因素相关的VOC.
- 在喘和COPD生物标志物发展的背景下,识别潜在的混VOC.
- 为开发呼吸道疾病的非侵入性点诊测试提供信息.
主要方法:
- 在PubMed,Embase和Cochrane图书馆 (2000-2022) 进行了PRISMA引导的系统文献搜索.
- 包括专注于呼出的呼吸中的VOC的研究.
- 数据进行了叙事合成,研究质量使用纽卡斯尔-太华尺度进行了评估.
主要成果:
- 从2209个记录中包括了24篇文章,确定了232个与风险因素相关的独特VOC.
- 58个VOC被多次报告,其中12个先前被认为是喘/COPD标志物.
- 包括的研究显示了方法异质性和可变的偏差风险.
结论:
- 确定了一系列与喘和/或COPD风险因素相关的呼气中的VOCs.
- 了解这些挥发性有机化合物对于推进基于呼出代谢物的临床试验至关重要.
- 需要进一步的研究来区分疾病特异性VOC与与风险因素相关的VOC.
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