在使用休息状态fMRI的失眠患者中,核 accumbens 功能连接
Fangjie Li1, Chengyong Liu2, Shan Qin2
1School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in neuroscience
|August 31, 2023
概括
患有失眠障碍 (ID) 的个人表现出脑部连接性减少,涉及到体核 (NAc). 这些功能异常可能作为诊断失眠和理解其神经基础的潜在生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 临床神经科学 临床神经科学
- 大脑的连接性 大脑的连接性
背景情况:
- 失眠障碍 (ID) 是一种普遍的疾病,影响全球数百万人.
- 了解ID的神经基础对于开发有效的治疗方法至关重要.
- 休息状态功能磁共振成像 (fMRI) 提供了对大脑功能的洞察.
研究的目的:
- 在患有失眠障碍 (ID) 的个体中,调查核 (NAc) 和整个大脑之间的功能异常.
- 探索导致ID的潜在神经机制.
- 识别潜在的神经成像生物标志物用于ID诊断.
主要方法:
- 招募了18名患有ID的参与者和16名正常对照者 (NC).
- 在NAc和全脑声细胞之间计算的静止状态功能连接 (FC).
- 使用的接收机运行特征 (ROC) 曲线分析和皮尔森相关性分析.
主要成果:
- 鉴定组在关键大脑区域 (如补充运动区域,中额头,中带带状和前状) 显著降低了FC值.
- 基于这些FC差异的分类模型实现了曲线下的面积 (AUC) 为83.3%.
- 异常的功能变化与疲劳严重程度等级 (R=0.650,p=0.004) 有正相关.
结论:
- 核 (NAc) 在失眠障碍 (ID) 的神经机制中发挥着重要作用.
- 涉及NAc的异常功能连接可能作为ID的潜在成像生物标志物.
- 这些发现增强了我们对失眠神经生物学的理解.
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