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内免疫疗法使用编码化学蛋白结构的mRNA,包括IL-12,CD137激动剂和TGF-β对抗剂

Assunta Cirella1,2, Elixabet Bolaños1,2, Carlos Luri-Rey1,2

  • 1Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain.

Molecular therapy. Nucleic acids
|August 31, 2023
PubMed
概括

编码介素-12 (IL-12) 的化学信使RNA (mRNA) 与向转化生长因子β (TGF-β) 和CD137的抗体融合,在小鼠模型中显示出强大的抗癌作用. 将内mRNA治疗与PD-1阻断相结合,可以增强这些治疗效益.

关键词:
在 4-1BBBB 中.在CD137中,CD137中,CD137中,CD137中在IL-12中,IL-12是最重要的.MT:交付策略的交付策略在TGF-β的基础上.局部免疫疗法 局部免疫疗法它们是mRNARNA.

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