为学生提供线粒体研讨会,以提高对科学和构建假设的理解
Andrea G Marshall1, Kit Neikirk1, Dominique Stephens1
1Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
Advances in physiology education
|August 31, 2023
概括
一个新的研讨会使用3D模型和实践活动来教中学生关于线粒体. 这种引人入胜的方法提高了他们对细胞生物学的理解,并激发了对科学事业的兴趣.
科学领域:
- 生理学 生理学 生理学
- 细胞生物学 细胞生物学
- 科学教育科学教育教育.
背景情况:
- 招募中学生,特别是来自代表性不足的背景的中学生,进入科学,技术,工程,数学和医学 (STEMM) 领域仍然是一个挑战.
- 在K-12教育和高等教育的科学实践之间经常存在脱节,这可能会阻碍学生的参与.
- 线粒体及其复杂的亚细胞结构为吸引年轻学习者参与生物科学提供了一个独特的入口点.
研究的目的:
- 为中学生开发和评估一个以线粒体结构和功能为重点的研讨会框架.
- 通过互动科学探索来培养批判性思维和假设形成技能.
- 增强学生对生理学和科学研究现实的理解.
主要方法:
- 实施一个使用三维视觉空间学习工具的研讨会.
- 整合实时批判性思维练习和假设形成活动.
- 采用混合和触觉学习方法来探索线粒体生物学.
主要成果:
- 中学学生对研讨会节目表现出积极的反应.
- 参与者报告说,他们对线粒体及其细胞作用有了更好的理解.
- 研讨会成功地使学生熟悉了科学研究和科学工作的性质.
结论:
- 实践性,引人入胜的课程可以有效地向中学生介绍复杂的生物学概念,如线粒体结构.
- 这种研讨会模型显示了在多样化的学生群体中增加对生理学和其他STEMM领域的兴趣的希望.
- 该框架可以适应不同的教育水平,包括高中和本科生,以促进科学参与.
相关概念视频
01:45Mitochondrial Membranes
11.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.6K
01:28The Inner Mitochondrial Membrane
3.4K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria. In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.4K
01:30Peroxisomes and Mitochondria
87.5K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
87.5K
01:22Chemiosmosis and ATP Synthesis
51
The electron transport chain is a critical component of cellular respiration, occurring in the inner mitochondrial membrane. It facilitates the transfer of high-energy electrons from reduced cofactors NADH and FADH₂ to molecular oxygen, the final electron acceptor. This transfer of electrons through a series of protein complexes is tightly coupled to the translocation of protons across the membrane, generating a proton gradient essential for ATP synthesis.Electron Flow and Proton...
51
01:22Introduction to Cellular Respiration
174.4K
Organisms harvest energy from food, but this energy cannot be directly used by cells. Cells convert the energy stored in nutrients into a more usable form: adenosine triphosphate (ATP).
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...
174.4K
01:21Structure of Porins
3.0K
Mitochondria, chloroplasts, and gram-negative bacteria have transmembrane, beta-barrel proteins called porins to mediate the free diffusion of ions and metabolites across the membrane. Mitochondrial porin precursors contain conserved amino acid sequences called beta signals at their C-terminal. Beta signals have a motif of PoXGXXHyXHy (Po-Polar, X-Any amino acid, G-Glycine, Hy-LargeHydrophobic), which are crucial for precursor recognition to initiate precursor assembly. Beta-barrel...
3.0K