[患有类风湿性疾病和肝功能异常的患者的临床特征]
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital,Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.
Zhonghua nei ke za zhi
|August 31, 2023
概括
肝功能异常在患有SLE和痛风等类风湿性疾病的患者中很常见,男性比女性更容易受到影响. 监测肝脏健康和使用保护性药物对于管理这些疾病至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
背景情况:
- 风湿性疾病往往涉及复杂的治疗方案,增加药物诱导的肝损伤的风险.
- 了解类风湿病患者肝功能异常的患病率和特征对于有效管理至关重要.
研究的目的:
- 为了研究患有类风湿性疾病和肝功能异常的患者的临床特征.
- 确定患有类风湿性关节炎 (RA),全身性红斑狼 (SLE),肖格伦综合征 (SS),化脊髓炎 (AS) 和痛风的患者肝功能异常的比例和严重程度.
主要方法:
- 一项横截面研究分析了中国风湿病日期中心 (2011-2021) 116,308名患者的数据.
- 人口统计数据,肝功能测试 (ALT,AST,ALP,胆红素) 和药物使用情况都被收集并与正常和异常肝功能组进行了比较.
- 根据不同类型的风湿性疾病的性别和年龄组分析了肝功能异常的比例.
主要成果:
- 在患有痛风 (28.73%) 和SLE (21.14%) 的患者中,肝功能异常的比例最高.
- 胺转移酶 (ALT) 的升高是最常见的异常,而酸酶 (ALP) 的升高是最不常见的.
- 在所有研究的类风湿性疾病中,男性的肝功能异常比女性更为普遍. 与年龄相关的趋势有所不同,Sjogren综合征的异常越来越多,痛风的趋势随着年龄的增长而下降.
结论:
- 风湿性疾病患者中很大一部分患有肝功能异常.
- 肝脏保护药物的低利用率凸显了患者护理方面的差距.
- 在风湿性疾病的管理过程中,加强肝功能监测和优化肝脏保护策略至关重要.
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