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青春期和成年期体重相关指标与抑郁症状之间的关系:来自两项双胞胎研究的结果
Ellen J Thompson1,2, Georgina Krebs1,3, Helena M S Zavos4
1MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Psychological medicine
|August 31, 2023
概括
体重指数 (BMI) 和抑郁症之间的联系在青春期是双向的,但变得单向,抑郁症在成年早期影响BMI. 遗传因素在这种关联中起着很小的作用.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 体重和抑郁症状之间的关系已经确立,但因果方向尚不清楚.
- 以前的研究主要使用身体质量指数 (BMI),缺乏对体重指标和抑郁症的病因研究.
研究的目的:
- 调查身体质量指数 (BMI) 和抑郁症状之间的关联的方向性.
- 探索遗传和环境对体重指标与整个发育过程中抑郁症之间的关系的影响.
主要方法:
- 利用双胞胎早期发育研究 (TEDS) 和英国成人双胞胎登记 (TwinsUK) 的数据.
- 采用表型交叉滞后面板模型和双胞胎数据的结构方程建模.
- 在多个时间点 (12,16,21岁) 评估了BMI和抑郁症状.
主要成果:
- 在TEDS中,在12-16岁之间观察到BMI和抑郁症之间的双向关系,BMI对抑郁症的影响更强烈.
- 从16岁起,这种关联变得单向,抑郁症预测21岁的BMI.
- 体重指数和抑郁症之间的小遗传相关性在16岁和21岁时被发现,但在12岁时没有.
结论:
- 体重指数-抑郁症关系的方向性对发育阶段敏感.
- 需要更大的,具有遗传信息的样本来准确估计病因影响.
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