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探索XIST轴作为系统性红血狼中与氧化压力相关的签名

Zhihan Chen1, Yunfeng Dai1, Yongxing Lai1

  • 1Fujian Medical University Provincial Clinical Medical College, Fuzhou, and Department of Rheumatology, Fujian Provincial Hospital, Fuzhou, China.

Clinical and experimental rheumatology
|August 31, 2023
PubMed
概括

这项研究确定了XIST/FOS和XIST/MME轴作为与氧化应激 (OS) 相关的系统性红斑狼 (SLE) 病原体的关键调节途径. 这些发现为SLE提供了潜在的新生物标志物和治疗点.

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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