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基于的矿纳米颗粒在呼吸系统中的肺毒性和分子机制

Xuefeng Ding^1,2,3, Rendong He^1,2,4, Tingjun Zhang^1,2,5

¹Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China.

ACS applied materials & interfaces

|August 31, 2023

概括

基于的矿纳米颗粒 (Pb-PNPs) 可以引起肺炎和纤维化. 这项研究揭示了它们的毒性机制,包括氧化应激和上皮细胞-介质细胞过渡,突出了安全问题.

科学领域:

纳米材料科学科学纳米材料科学
毒理学毒理学毒理学
呼吸系统医学呼吸系统医学

背景情况:

基于的矿纳米颗粒 (Pb-PNPs) 广泛使用,但由于稳定性和水溶性不佳,引起了环境和健康方面的担忧.
吸入是人类对Pb-PNPs的主要暴露途径,需要对呼吸道毒性进行调查.

研究的目的:

为了研究化 PeroVskite纳米颗粒 (CsPbBr3 NPs) 对呼吸系统的有毒作用.
阐明CsPbBr3 NP诱导的肺毒性背后的分子机制.

主要方法:

在体外细胞毒性测试和电子显微镜被用来研究CsPbBr3NP在BEAS-2B肺细胞中.
在CsPbBr3NP的鼻内注射后,在ICR小鼠中评估了体内生物分布和肺毒性.

主要成果:

CsPbBr3 NPs在BEAS-2B细胞中诱导了显著的氧化应激和亡.
CsPbBr3 NPs招募了TGF-β1,从而在体外引发了上皮细胞-介质细胞过渡 (EMT).
在小鼠中,CsPbBr3 NPs的鼻内注射导致肺炎,EMT和纤维化.

结论:

CsPbBr3 NPs在呼吸系统中表现出显著的毒性,诱导炎症,EMT和潜在的纤维化.
了解分子机制,包括氧化应激和TGF-β1信号,对于评估Pb-PNP的安全性至关重要.
这些发现有助于Pb-PNPs的安全数据,特别是在吸入暴露方面.

关键词:

灭症 (apoptosis) 是一种死亡的过程.细胞毒性细胞毒性基于的矿纳米颗粒.肺部毒性肺部毒性肺部毒性肺部纤维化肺部纤维化

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