后COVID-19密码化症:一个严重的风险或仅仅是协会?
A E Enas1,2, M A Hadel3, A A Emad4
1Medical Parasitology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Tropical biomedicine
|August 31, 2023
概括
在COVID-19后,患有Cryptosporidium感染的患者经历了胃肠道问题恶化和炎症标志物升高. 某些抗COVID-19药物增加了感染风险,突出了寄生虫感染和长期COVID症状之间的联系.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 后COVID-19条件呈现各种健康问题,包括胃肠道问题.
- 后COVID-19条件与寄生虫感染 (特别是Cryptosporidium) 之间的关联仍未得到充分研究.
- 了解这些联系对于全面的患者管理至关重要.
研究的目的:
- 为了调查Cryptosporidium感染在COVID-19后病情患者中的流行率和影响.
- 分析胃肠道症状,便生物标志物和与Cryptosporidium感染有关的病史.
- 探索抗COVID-19疗法与Cryptosporidium感染风险之间的关联.
主要方法:
- 对210名COVID-19后患者的胃肠道症状,病史和COVID-19感染状况的分析.
- 使用RFLP检测和分子表征便中的Cryptosporidium卵囊.
- 测量便生物标志物: H. pylori,隐性血液,便calprotectin (FCAL) 和TNF-a. 这些都是便生物标志物.
主要成果:
- 在COVID-19后的患者中,Cryptosporidium感染与慢性腹,吐和体重减轻有关.
- 与对照组相比,COVID-19后的Cryptosporidium患者表现出较高的H. pylori,FCAL,TNF-a和隐性血液水平.
- 亚齐思罗密,化和艾弗梅克丁的使用与增加Cryptosporidium感染的风险有关.
结论:
- 在COVID-19后的患者中,Cryptosporidium卵囊与恶化的胃肠道症状和便生物标志物的增加显著相关.
- 某些抗COVID-19治疗可能会增加Cryptosporidium感染的风险.
- 这项研究强调了在管理COVID-19后的胃肠道并发症时考虑寄生虫感染的重要性.
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