肝炎C和心脏移植:最新情况
Marina Nunez1, Anita A Kelkar2
1Department of Internal Medicine, Section on Infectious Diseases, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, USA.
Clinical transplantation
|August 31, 2023
概括
由于直接作用的抗病毒疗法,肝炎C病毒 (HCV) 感染的患者现在可以进行心脏移植. 使用HCV阳性捐赠器官的数量有所增加,早期生存数据与HCV阴性接受者相比没有差异.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 移植医学 移植医学
背景情况:
- 从历史上看,型肝炎病毒 (HCV) 感染对心脏移植结果造成了重大关注.
- 对捐赠者和接受者的HCV状况存在担忧,移植频率和器官利用率受到限制.
研究的目的:
- 在HCV感染的背景下,审查心脏移植的不断变化的格局.
- 评估直接作用抗病毒药物 (DAA) 和改进的诊断对移植实践和结果的影响.
主要方法:
- 文学综述检查心脏移植的DAA前和DAA时代.
- 对感染HCV的接受者和使用HCV阳性供体器官的结果的分析.
主要成果:
- 直接作用的抗病毒疗法已经改变了HCV的治疗方法,消除了它作为移植障碍.
- 对HCV感染者和未感染者的HCV阳性器官的使用显著增加.
- 在DAA时代的短期存活数据表明HCV感染者与未感染的心脏移植接受者之间的平价.
结论:
- 冠状病毒感染不再是心脏移植的绝对禁忌.
- 通过令人鼓舞的初步结果,支持增加HCV阳性捐赠器官的利用率.
- 需要进一步的长期安全数据,以充分优化该实践的协议.
相关概念视频
Kidney Transplant I: Introduction
28
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
28
Tissue Transplantation
396
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
396
Cardiomyopathy V: Interprofessional Care
14
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
14


