阿片类药物诱导的的机制和治疗:外围和中央通路
Hiroai Okutani1,2, Silvia Lo Vecchio1, Lars Arendt-Nielsen1,3,4
1Center for Neuroplasticity and Pain, SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.
European journal of pain (London, England)
|August 31, 2023
概括
阿片类药物诱导的或是挑战疼痛管理的常见副作用. 结合μ-阿片类药物抗剂和k-阿片类药物激动剂提供了一个有前途的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- () 是一种不愉快的感觉,通常是由阿片类药物引起的,尽管它们具有止痛作用.
- 阿片类药物诱导的的神经生物学是复杂的,涉及与疼痛共享的途径,并且仍然不完全理解.
- 控制阿片类药物诱导的是一个重要的临床挑战在疼痛管理.
研究的目的:
- 审查目前关于阿片类药物诱导的机制的文献.
- 探索阿片类药物诱导的和止痛之间的关系.
- 总结阿片类药物诱导的的潜在治疗选择.
主要方法:
- 这项研究是对现有科学文献的叙事性审查.
- 它综合了关于阿片类药物诱导的的神经生物学机制的发现.
- 它讨论了当前和潜在的治疗策略.
主要成果:
- 由阿片类药物引起的发病率因阿片类药物的类型和服用途径而异.
- 机制被广泛分为外围和中心,复杂的中心通路.
- μ-阿片类药物抗剂和 κ-阿片类药物激动剂在缓解阿片类药物诱导的方面表现出有效性,尽管治疗方法仍然存在争议.
结论:
- 结合μ-阿片类药物抗剂和k-阿片类药物激动剂的多模式方法是当前管理阿片类药物诱导的和疼痛的最佳实践.
- 对阿片类药物诱导的的有效管理策略对于患者护理至关重要,特别是在管理严重疼痛时.
- 对阿片类药物诱导的的机制和治疗方法的进一步研究是必不可少的.
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