псилоцибин史,作用和反应:一个叙述性的临床综述
Pravesh Sharma1,2, Quang Anh Nguyen2, Sadie J Matthews3
1Department of Psychiatry and Psychology, Mayo Clinic Health System, Eau Claire, WI, USA.
Journal of psychopharmacology (Oxford, England)
|August 31, 2023
概括
松素辅助疗法对抑郁症,焦虑症和酒精使用障碍有很大的前景,但副作用一般是轻微的. 需要进一步的研究来证实在不同患者群体的有效性和安全性.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 临床精神病学 临床精神病学
背景情况:
- 幻觉中的精神活性化合物psilocybin正受到潜在的治疗应用的关注.
- 历史上的仪式使用与现代对治疗情绪和物质使用障碍 (SUDs) 的兴趣形成鲜明对比.
- 美国一些州最近的立法变化凸显了对西风险和益处的临床理解的需要.
研究的目的:
- 审查精神疾病和SUDs中psilocybin辅助治疗的科学基础和临床证据.
- 讨论psilocybin的历史,作用机制和不断变化的法律地位.
- 为了告知临床医生如何向患者提供关于西治疗的建议.
主要方法:
- 专家对现有科学文献和临床试验数据进行叙述性审查.
- 分析了psilocybin的疗效和安全性.
- 检查影响psilocybin使用的立法趋势.
主要成果:
- 适度的证据支持用于抑郁症和焦虑障碍的 псилоцибин辅助治疗.
- 早期数据表明,它在减少酒精使用障碍症状方面具有潜在的有效性.
- 在监督下服用时,副作用通常是轻微的和短暂的;严重的不良事件不常见,但需要进一步研究.
结论:
- 松素辅助疗法为特定精神疾病和SUDs提供了潜在的新疗法途径.
- 持续调查至关重要,以确定最佳的患者群体,并充分了解安全概况,包括在一些试验中观察到的潜在风险,如增加的自杀念头.
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