在任何水平的肥胖,相对较高的瘦素度与胰岛素敏感性降低有关
Martina Chiriacò1, Lorenzo Nesti1, Allan Flyvbjerg2
1Metabolism, Nutrition, and Atherosclerosis Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
The Journal of clinical endocrinology and metabolism
|August 31, 2023
概括
素水平高于体脂预期的个体表现出胰岛素耐药性和更高的胰岛素水平,不管身体质量指数 (BMI). 这突出了勒素的作用.
科学领域:
- 代谢健康 代谢健康
- 内分泌学 在内分泌学.
- 肥胖问题研究研究
背景情况:
- 肥胖对葡萄糖平衡的影响的个体间变化可能源于不同的阿迪波金水平.
- 对于能量平衡至关重要的瘦素,尽管与脂肪质量有成比例的关系,但其血水平显示出显著的个体变化.
研究的目的:
- 为了调查葡萄糖稳态是否在具有相似脂肪但具有不同莱普丁水平的个体之间存在差异.
主要方法:
- 从胰岛素敏感性与心血管疾病之间的关系研究中对1290名健康成年人 (30-60岁) 的分析.
- 评估身体组成,代谢变量,耐葡萄糖,胰岛素敏感性 (euglycemic-hyperinsulinemic),β细胞功能和脂质学.
- 根据性别特异性瘦素-脂肪质量回归,将其分为相对高的瘦素 (RHL) 和低的瘦素 (RLL) 组.
主要成果:
- 尽管RHL个体的葡萄糖耐受性相似,但与RLL相比,RHL个体的禁食和后葡萄糖胰岛素度和分泌量显著更高.
- 不管BMI,RHL个体表现出较低的全身和脂肪组织胰岛素敏感性.
- 瘦RHL个体表现出与超重/肥胖RLL个体相比的胰岛素敏感性和β细胞功能.
结论:
- 相对于脂肪质量来说,不适当的升高的丁水平与全身和脂肪组织的胰岛素抵抗有关.
- 超胰岛素血症 (hyperinsulinemia) 观察到的个体与他们的脂肪不成比例的瘦素水平,独立于BMI.
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