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HMDD v4.0:一个实验支持的人类微RNA疾病关联的数据库

Chunmei Cui¹, Bitao Zhong¹, Rui Fan¹

¹Department of Biomedical Informatics, Center for Noncoding RNA Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.

Nucleic acids research

|August 31, 2023

概括

人类微RNA疾病数据库 (HMDD) v4.0现在包括53530个miRNA疾病关联,扩大了它对研究人员的实用性. 这一更新包含了关于外体和病毒编码的miRNA以及miRNA-circRNA相互作用的新数据.

科学领域:

生物化学生物化学
遗传学是一个遗传学.
生物信息学是一种生物信息学.

背景情况:

微RNA (miRNA) 是重要的小型非编码RNA,调节生物过程.
miRNAs是疾病诊断和治疗策略的重要生物标志物.
人类微RNA疾病数据库 (HMDD) 是miRNA相关医学研究的关键资源.

研究的目的:

引入HMDD v4.0,一个更新的miRNA疾病关联的全面数据库.
扩大精选数据的范围,包括与疾病机制相关的新类别.
促进基于miRNA的诊断和治疗研究.

主要方法:

从科学文献中整理了53,530个miRNA-疾病关联条目.
整合新的数据类别:外体miRNA,病毒编码miRNA和miRNA-circRNA相互作用.
纳入关于疾病中的性别偏差miRNAs的精选数据.

主要成果:

HMDD v4.0包含的条目数量是前一个版本 (HMDD v3.0) 的1.5倍.
数据库现在包括与外体miRNAs,病毒编码miRNAs和miRNA-circRNA相互作用相关的关联.
一个案例研究表明,性别偏差的miRNA与特定性别的人类疾病有关.

结论:

HMDD v4.0代表了对miRNA疾病研究的显著扩展和丰富的资源.
新类别的加入增强了对涉及miRNAs的复杂疾病机制的理解.
该数据库为人类疾病中的性别偏差miRNA角色提供了有价值的见解.

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