在全身性硬化症临床试验中评估疾病损伤,疾病严重程度和治疗反应的综合措施
Laura Ross1,2, Mandana Nikpour1,2
1Department of Medicine at St Vincent's Hospital, University of Melbourne.
Current opinion in rheumatology
|August 31, 2023
概括
研究人员正在开发综合结果措施,以评估系统性硬化症 (SSc) 的影响. 最近的进展包括SSc特定的损伤指数,患者报告的结果和临床试验中的治疗反应.
科学领域:
- 类风湿病学 类风湿病学
- 临床试验 临床试验
- 结果测量 结果测量
背景情况:
- 系统性硬化症 (SSc) 显著影响患者.
- 开发SSc的综合结果指标对于研究和临床实践至关重要.
研究的目的:
- 总结现有的综合结果措施,以评估系统性硬化症 (SSc) 疾病损伤,严重程度和治疗反应.
主要方法:
- 审查最近在开发和验证SSc的复合成果措施方面的努力.
- 包括共识和数据驱动的方法.
主要成果:
- 最近的发展包括SSc特定的损害指数,患者报告的疾病影响问卷 (ScleroID) 和ACR-CRISS治疗响应指数.
- 在临床试验中,复合测量越来越多地用于评估治疗疗效.
结论:
- 在制定SSc治疗反应,损害和整体影响的措施方面取得了重大进展.
- 虽然尚未完全验证的疾病特异性复合测量方法,但目前的进展支持其在随机对照试验中的应用.
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