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一种生物活性可分解的聚合物纳米粒子,用于协同作用的血管抗化

Hossein Adelnia^1,2, Shehzahdi Shebbrin Moonshi¹, Yuao Wu¹

¹Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, Queensland 4111, Australia.

|August 31, 2023

概括

携带黄素的向纳米颗粒通过释放聚酸和黄素有效抑制血管化,防止细胞分化并减少体内沉积,副作用最小.

科学领域:

生物材料科学生物材料科学
纳米医学是一种纳米医学.
血管生物学血管生物学

背景情况:

血管化是心血管疾病的重要危险因素.
聚酸 (PASP) 显示出抑制血管化的潜力,但存在管理方面的挑战.
纳米颗粒药物递送系统为克服这些局限性提供了一个有希望的方法.

研究的目的:

开发以聚苏胺基为基础的向纳米粒子 (PSI NPs),作为增强血管抗化疗法的前药物和载体.
为了研究含有黄素 (Cur) 的PSINP对协同血管抗化作用的有效性.
在体外和体内评估Cur载PSINP的安全性和治疗潜力.

主要方法:

用于PASP输送的基于聚苏胺的纳米颗粒 (PSI NPs) 的合成和表征.
将疏水性黄素 (Cur) 封装成具有高负载效率的PSI NP.
在实验室中评估NP稳定性,在生理和酸性条件下的药物释放动力学,以及对血管光滑肌细胞 (VSMC) 和巨细胞的影响.
在鼠模型中Cur-loaded PSI NPs的体内评估由腺素食诱导的血管化,包括组织学和血清生物化学分析.

主要成果:

在生理条件下,PSI NPs在16小时内表现出稳定性,在48小时内缓慢释放治疗性PASP和Cur.
库尔加载的PSI NPs表现出pH依赖的药物释放,在酸性条件下释放有限.
虽然PSI NPs阻止了沉积,但加Cur的PSI NPs也抑制了VSMC骨质分化,并降低了巨细胞中的ROS水平.
在体内研究表明,在接受Cur-loaded PSI NPs治疗的老鼠中,大动脉化显著减少,对骨完整性或显著毒性没有不良影响.

结论:

化学修饰的PSINP作为有效的纳米载体用于疏水性药物,具有抗化和抗ROS活性.
库尔加载的PSINP提供了协同治疗效果,解决沉积和VSMC骨质分化的问题.
这种新型纳米医学方法显示出治疗血管化的巨大潜力,并提高了安全性.

关键词:

这是一种反化,反化.抗氧化剂是一种抗氧化剂.慢性脏疾病慢性脏疾病库尔库明是一种黄素.聚苏胺胺是什么?血管化血管化

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