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在扩散型大B细胞淋巴瘤中,过去乙型肝炎病毒感染的高患病率:意大利的一项回顾性研究
Marcella Visentini1, Andrea Pica2, Giancarlo D'Ippolito2
1Division of Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy. marcella.visentini@uniroma1.it.
Annals of hematology
|August 31, 2023
概括
乙型肝炎病毒 (HBV) 感染,无论是活跃的还是过去的,都与扩散性大B细胞淋巴瘤 (DLBCL) 的更高风险有关. 这一发现来自于一项在低流行地区的研究,表明HBV和DLBCL风险之间存在更广泛的关联.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 乙型肝炎病毒 (HBV) 感染与高流行地区扩散性大B细胞淋巴瘤 (DLBCL) 的风险增加有关.
- 在低流行地区,关于HBV感染和DLBCL风险存在相互矛盾的结果.
- 过去的HBV感染也与B细胞非霍奇金淋巴瘤 (NHL) 风险有关.
研究的目的:
- 调查过去和活跃的HBV感染与DLBCL风险在低流行地区之间的关联.
- 为了比较DLBCL患者的HBV血清状况与惰的B细胞NHL.
主要方法:
- 意大利253名DLBCL患者和694名惰B细胞NHL患者的回顾性审查 (2001-2022年).
- 使用免疫试验和分子方法分析HBV血清标记物 (HBsAg,HBsAb,HBcAb,HBeAg,HBeAb,HBV DNA).
- 无条件的多重物流回归调整性别,年龄和移民身份.
主要成果:
- DLBCL患者的活跃HBV感染 (HBsAg阳性) 患病率较高,相比不活跃的NHL患者 (OR 2.8,p=0.014).
- 在DLBCL患者中,过去的HBV感染 (HBsAg阴性,HBcAb阳性) 的患病率也显著增加 (OR2.4,p=0.0006).
- 男性性别是DLBCL的独立风险因素.
结论:
- 活跃的和过去的HBV感染都可能增加DLBCL的风险在低特有环境中.
- 研究结果表明,HBV在DLBCL病变发生过程中的作用可能超出高度特有地区.
- 需要对不同种群进行进一步的研究来证实这些关联.
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