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增加的D-二聚合物和纤维素降解产品水平作为评估感染相关急性疹的潜在指标:个案对照研究
Lei Zhang1, Weiwei Jiang2, Yacob Berhane Gebreab3
1Department of Dermatology, Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Archives of dermatological research
|August 31, 2023
概括
凝血标记物如D-二聚体和纤维素降解产物 (FDP) 可以帮助识别与感染相关的急性疹. 监测这些标志物有助于对急性疹患者的临床管理.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 急性疹影响全球大约20%的人口.
- 在慢性疹中观察到凝血功能障碍,但其在急性疹中的作用尚不清楚.
- 从临床上来说,区分与感染相关的急性疹与与感染无关的急性疹是非常重要的.
研究的目的:
- 为了研究急性疹患者的凝血变化.
- 为了比较与感染相关的和与感染无关的急性疹之间的凝血参数.
- 评估凝血标志物在急性疹中显示感染的潜力.
主要方法:
- 58名急性疹患者被分为与感染有关的和与感染无关的两组.
- 常规实验室参数,包括凝血测试 (D-二聚合物,FDP,纤维素原,APTT) 和CRP,在各组之间进行了比较.
- 分析了急性和缓解阶段凝血试验的动态变化.
主要成果:
- 与感染相关的急性疹在急性阶段显示D-二聚合物,FDP和纤维素原的升高.
- 在急性阶段,D-二聚合物,FDP,纤维素和APTT与C反应蛋白 (CRP) 有正相关.
- 较高的D-二分体 (>0.48 mg/L) 和FDP (>3.84 mg/L) 水平表明与感染相关的急性疹.
结论:
- 结血标志物,特别是D-二次体和FDP,在与感染相关的急性疹中发生变化.
- D-二聚合物和FDP水平的动态变化可以帮助临床管理.
- 这些标记物可以作为急性疹患者感染的指标,这些患者有低静脉血栓栓塞的风险.
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