在有或没有癌症的成年人中,SARS-CoV-2感染,住院和死亡率
Seyed M Hosseini-Moghaddam1,2,3, Frances A Shepherd4,5, Sarah Swayze1
1ICES, Toronto, Ontario, Canada.
JAMA network open
|August 31, 2023
概括
癌症患者面临来自SARS-CoV-2的更高风险. 血液癌症增加了感染和死亡率,而固体瘤增加了住院和死亡风险. 接种疫苗显著降低了感染风险.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 癌症患者患有与SARS-CoV-2感染相关的不良结果的风险更高.
- 了解不同类型癌症带来的具体风险对于患者管理和公共卫生战略至关重要.
研究的目的:
- 调查瘤类型与SARS-CoV-2感染,住院,重症监护室 (ICU) 入院和死亡率之间的关联.
- 为了确定特定的癌症诊断,从而增加COVID-19不良结果的风险.
主要方法:
- 在加拿大安大略省使用省级卫生数据库进行了回顾性,基于人口的队列研究 (2020年1月 - 2021年11月).
- 包括超过1170万成年人,分析使用Cox比例危险模型的关联.
- 主要结局:SARS-CoV-2感染;次要结局:住院,ICU入院和死亡.
主要成果:
- 患有血液性恶性瘤的个体患有SARS-CoV-2感染,住院和死亡的风险增加.
- 固体瘤患者感染风险较低,但住院和死亡风险增加.
- 接种COVID-19疫苗显著降低了SARS-CoV-2感染风险,随着剂量增加,观察到风险逐步降低.
结论:
- 癌症患者,特别是患有血液性恶性瘤的患者,面临SARS-CoV-2的风险增加.
- 对ICU接入的优先级策略可能是必要的,以减轻高风险癌症人群的死亡率.
- 疫苗接种是癌症患者对SARS-CoV-2感染的关键保护措施.
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