脑癌患者接受免疫疗法治疗的差异
Shreya P Ramkumar1, Arun Bhardwaj2, Amila Patel2
1currently a medical student at Saint Louis University School of Medicine, St Louis, Missouri.
JAMA otolaryngology-- head & neck surgery
|August 31, 2023
概括
患有头部和部平细胞癌 (HNSCC) 的白人患者接受免疫治疗的几率更高. 这表明在癌症护理获取方面存在潜在的差异,需要解决这些差异,以改善所有患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 健康差异 在健康上的差异
背景情况:
- 免疫检查点抑制剂 (免疫疗法) 在2016年被批准用于头部和部状细胞癌 (HNSCC).
- 在HNSCC患者中接受免疫治疗的潜在临床或社会人口统计差异尚不清楚.
- 已知在头癌治疗中的差异需要对免疫治疗的准入进行调查.
研究的目的:
- 确定与老年HNSCC患者接受免疫治疗相关的临床和非临床因素.
- 根据患者特征,调查免疫疗法利用的潜在差异.
主要方法:
- 对4860名65岁或以上的患者进行了回顾性队列研究,诊断出HNSCC.
- 2017年1月至2022年4月在社区瘤学环境中分析电子健康记录.
- 多变量后勤回归用于评估包括瘤阶段,亚部位,年龄,种族,种族,种族,性别和吸烟史等因素.
主要成果:
- 11.4%的患者接受了免疫疗法.
- 与其他种族相比,白人患者接受免疫治疗的几率增加了80% (AOR,1.80).
- 先进阶段 (AOR,2.39) 和非耳鼻部部位 (AOR,1.29) 与更高的免疫疗法接收相关.
结论:
- 老年白人患有HNSCC的患者可能更有可能接受免疫疗法.
- 公平获得免疫治疗对于减少与癌症相关的健康差异至关重要.
- 解决差异可以提高HNSCC患者的生存率.
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