在复发性结肠癌中的身体活动:癌症和白血病组B/SWOG 80702 (联盟)
Justin C Brown1,2,3, Chao Ma4, Qian Shi5
1Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Cancer
|August 31, 2023
概括
在第三阶段结肠癌手术后增加体力活动与瘤复发后更好的存活率有关. 定期炼可以改善高风险患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 流行病学 流行病学
背景情况:
- 第三阶段结肠癌复发影响三分之一的患者.
- 身体活动对复发后生存率的影响尚不清楚.
- 手术后的化疗是治疗第三阶段结肠癌的标准.
研究的目的:
- 在第三阶段结肠癌患者中调查瘤复发后的身体活动和整体存活率之间的关联.
- 量化较高体力活动水平对生存的益处.
- 为患有复发高风险的患者提供临床建议.
主要方法:
- 随机多中心试验中的前性队列研究 (N=399).
- 在复发之前测量了手术后体力活动能量消耗 (MET-h/week).
- 使用多变量灵活的参数生存模型分析复发后的整体生存率.
主要成果:
- 身体活动较高的患者 (≥18.0MET-h/周) 与较低的活动 (<3.0MET-h/周) 相比,在复发后的整体生存率相对改善了33%.
- 高活动群体的三年生存率为72.2%,低活动群体为61.3%.
- 较高的体力活动与改善的生存结果有显著的关联.
结论:
- 术后体力活动增加与III期结肠癌瘤复发后的整体存活率提高有关.
- 这些发现表明,身体活动可能是高风险患者的有益补充.
- 进一步的研究可以探索运动干预措施以改善患者的治疗结果.
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