破坏虫害:肠道微生物代谢饮食成分并调节血管健康
Adhini Kuppuswamy Satheesh Babu1, Harini Srinivasan1, Pon Velayutham Anandh Babu1
1Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, Utah, USA.
Critical reviews in food science and nutrition
|August 31, 2023
概括
饮食和肠道微生物通过微生物代谢产物显著影响血管健康. 有益的代谢物改善血管,而有害的代谢物损害血管,突出了未来研究的关键领域.
科学领域:
- 微生物组研究的研究.
- 血管生物学 血管生物学
- 代谢学 代谢学 代谢学
背景情况:
- 饮食深刻地塑造了肠道微生物组的组成和功能.
- 肠道微生物产生代谢物,影响宿主生理和疾病.
- 饮食与微生物的相互作用对于保持血管健康至关重要.
研究的目的:
- 探索饮食衍生微生物代谢物在血管健康中的作用.
- 识别影响血管系统的有益和有害代谢物.
- 突出了解饮食-微生物-血管相互作用的知识差距.
主要方法:
- 对短链脂肪酸和酸代谢物的分析.
- 对三甲基胺N-氧化物和氨基酸衍生代谢物的研究.
- 对血液血管中代谢物-点相互作用的现有证据的审查.
主要成果:
- 特定的微生物代谢物,如短链脂肪酸,增强血管健康.
- 其他代谢物,如三甲基胺N-氧化物,对血管功能产生负面影响.
- 代谢物影响关键的血管过程,包括血压,炎症和动脉样硬化.
结论:
- 饮食成分,肠道微生物及其代谢物是血管健康的核心.
- 在了解微生物酶作用,食物矩阵效应和代谢物结构-活性关系方面存在重大差距.
- 未来的研究应该整合多学科的方法,以阐明发展血管健康干预的因果关系.
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