埃莫丁通过HMGB1/TLR4/NF-κB分子通路在PCOS小鼠中改善葡萄糖代谢和卵巢功能
Antonia Otoo1,2, Armin Czika2,3, Jones Lamptey2
1Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Reproduction (Cambridge, England)
|August 31, 2023
概括
通过潜在地准HMGB1/TLR4/NF-kB途径,埃莫丁治疗改善了肥胖的PCOS小鼠的葡萄糖代谢和卵巢功能,为多囊性卵巢综合征 (PCOS) 提供了潜在的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 生殖科学 生殖科学
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,影响全球5-10%的女性,其特点是代谢和生殖功能障碍.
- 在PCOS患者中经常观察到肥胖和葡萄糖代谢受损.
- 高流动性组盒1 (HMGB1) 蛋白质与葡萄糖代谢受损和PCOS病原体有关.
研究的目的:
- 在PCOS小鼠模型中研究emodin对葡萄糖代谢和卵巢功能的治疗潜力.
- 探索 HMGB1/TLR4/NF-kB 信号通路在 emodin 对 PCOS 的影响中的作用.
主要方法:
- 在PCOS小鼠模型中,使用高脂肪饮食 (HFD) 和脱氨 (DHEA) 诱导PCOS.
- 小鼠接受了埃莫丁或车载控制器的治疗.
- 在卵巢和血清组织中评估了代谢参数 (葡萄糖水平,胰岛素抵抗),激素配置 (LH,),卵巢形态和分子标记 (HMGB1,TLR4,NF-kB,GLUT4,IRS2,INSR).
主要成果:
- 在PCOS小鼠中,Emodin的使用减轻了肥胖,高血糖,葡萄糖不耐受和胰岛素抵抗.
- 埃莫丁治疗改善了多囊性卵巢形态,并降低了血清HMGB1,LH和的升高水平.
- 埃莫丁降低了卵巢HMGB1,TLR4和NF-kB/65的表达,同时增加了GLUT4,IRS2和INSR水平.
结论:
- 埃莫丁有效地缓解了PCOS小鼠的代谢和生殖障碍.
- 埃莫丁的治疗作用可能通过HMGB1/TLR4/NF-kB信号通路进行介导.
- 埃莫丁显示出作为管理PCOS的潜在治疗剂的希望.
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