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益生菌:它可以调节骨折愈合吗?
Yufa Wang1,2, Aouod Agenor1,2, Allison Clement1,2
1Sunnybrook Research Institute, Toronto, ON, Canada.
PloS one
|August 31, 2023
概括
在骨折前服用口服益生菌显著增强了小鼠的骨愈合标志物和生物力学特性. 骨折后的益生菌治疗显示了一些好处,但在改善骨愈合方面效果不佳.
科学领域:
- 整形外科 整形外科 整形外科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 骨折严重损害了功能和生产力.
- 肠道微生物群影响宿主生理学,包括骨代谢.
- 优化骨折愈合对于患者的康复至关重要.
研究的目的:
- 为了研究口服益生菌治疗对骨折后骨愈合的影响.
- 评估益生菌管理后细胞因子和骨生物标记物的变化.
- 评估益生菌对愈合骨的生物力学特性的影响.
主要方法:
- 在C57BL/6小鼠中,进行了大腿骨切除术和内钉.
- 益生菌或对照治疗在骨折前 (5周) 或骨折后 (4周) 进行口服.
- 骨质原性细胞因子和生物标志物的基因表达通过RT-qPCR进行了分析.
- 微结构分析 (μCT) 和生物力学测试 (扭曲) 评估了愈合的股骨.
主要成果:
- 骨折前益生菌治疗增加了关键细胞因子 (TGF-β,IL-6,IL-17F) 和骨标记物 (Col1,Runx2).
- 在骨折前的治疗中,骨体积,密度,扭矩,刚度和应变能量的显著改善被观察到.
- 骨折后治疗没有显示基因表达或微观结构的显著变化,但改善了一些失败生物力学.
结论:
- 在骨折前服用口服益生菌可以增强骨愈合和生物力学强度.
- 益生菌的使用可能为骨折愈合提供低风险,低成本的辅助疗法.
- 益生菌管理的时间对于优化骨愈合结果至关重要.
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