来自乌干达艺术经验丰富的艾滋病毒阳性成年人的呼吸道样本中的细菌特征和抗生素敏感性模式
Gloria Lubega1, Andrew Abaasa1,2, Willyfred Ochola1
1Medical Research Council /Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
耐药细菌在艾滋病毒感染者 (PLWH) 中很常见,导致严重的健康问题. 从PLWH中分离出的大多数细菌对常见抗生素的敏感性较低,需要采取紧急行动.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 微生物感染,特别是呼吸道感染 (RTIs),是艾滋病毒感染者 (PLWH) 的疾病和死亡的主要原因.
- 在PLWH中耐药细菌的高患病率构成了严重的公共卫生问题.
研究的目的:
- 调查来自PLWH的唾液样本中的细菌病原体的流行率.
- 为了确定孤立细菌的抗微生物敏感性模式.
主要方法:
- 对COSTOP试验 (2011-2013) 数据的回顾性分析.
- 用Gram和Ziehl-Neelsen染料分析了唾液样本,并进行培养.
- 针对单独的病原体,使用光盘扩散方法进行了对抗菌素敏感性测试.
主要成果:
- 在687名参与者中,201个唾液样本产生了细菌生长,其中Moraxella物种,Streptococcus pneumoniae和Haemophilus流感是最常见的.
- 较高的月收入和自艾滋病毒诊断以来的更长时间与积极的细菌培养有关.
- 大多数细菌分离物对和红素的敏感性较低,但对阿莫西西林/克拉夫兰酸和 ceftriaxone 显示出敏感性.
结论:
- 细菌对通过国家供应链获得的常见处方抗生素的敏感性非常低,这是一个公共卫生问题.
- 需要紧急干预,以解决PLWH中抗菌素耐药性高率的问题.
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