边缘味觉神经元的快速结构改造是独立于味觉细胞周转率的
Zachary D Whiddon1, Jaleia B Marshall1, David C Alston1
1Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.
PLoS biology
|August 31, 2023
概括
味觉质神经元在味蕾内迅速重塑它们的终端分支,独立于味觉细胞的循环. 这种可塑性允许神经元与新细胞连接,同时保持稳定的整体结构,以保持一致的味觉感知.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 感官系统 感官系统
背景情况:
- 味蕾细胞不断更新,需要新的细胞与神经回路集成.
- 味蕾神经元的动态重塑以适应味蕾细胞的周转仍然不太了解.
研究的目的:
- 为了研究味蕾内的味道团神经元树木的结构性塑性和重塑.
- 为了确定味蕾细胞更新和味蕾改造之间的关系.
主要方法:
- 利用两光子体内显微镜来跟踪老鼠随着时间的推移对个体味道树的运动和分支.
- 使用化疗剂阻止新的味蕾细胞进入,并评估重塑独立性.
主要成果:
- 味觉树的末端分支表现出快速,连续的重塑 (增加和损失),超过了味蕾细胞更新的速度.
- 末端分支的重塑独立于新的味蕾细胞的结合而发生.
- 虽然个别的树枝迅速重塑,但每味蕾的树木总数在长时间内保持稳定.
结论:
- 味道腺神经元树木具有内在的可塑性,可以快速重塑终端分支.
- 稳定的Arbor数确保了尽管细胞周转,持续的神经连接和功能.
- 终端分支的可塑性有助于适应新的味蕾细胞,保持感官感知.
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