对于患有需要透析的功能衰竭患者的疲劳干预措施
Patrizia Natale1,2,3, Angela Ju2, Giovanni Fm Strippoli1,2,4
1Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J) Nephrology, Dialysis and Transplantation Unit, University of Bari Aldo Moro, Bari, Italy.
The Cochrane database of systematic reviews
|August 31, 2023
概括
疲劳是透析患者常见和衰弱的症状. 运动,芳香疗法,按摩和针可以改善疲劳,但对其他干预措施需要更多的研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床试验 临床试验
- 基于证据的医学基于证据的医学.
背景情况:
- 疲劳是接受透析 (血液透析[HD]和腹腔透析[PD]) 的患者普遍和严重的症状.
- 这种症状与增加的死亡率,心血管疾病,抑郁症和降低生活质量 (QoL) 有关.
- 疲劳被患者,护理人员和医疗保健专业人员认为是透析患者的关键结果.
研究的目的:
- 评估药理和非药理干预措施对接受透析的个体的疲劳管理的有效性.
- 评估各种透析设置和频率的干预措施.
主要方法:
- 在2022年10月18日之前,对科克伦脏和移植研究注册表进行了全面的搜索.
- 包括94项研究,8191名参与者,比较干预与安慰剂,对照或其他治疗.
- 进行了数据提取,偏差风险评估和元分析 (使用随机效应模型),使用GRADE方法评估证据的信心.
主要成果:
- 低确定性证据表明,与对照组或安慰剂相比,运动,芳香疗法,按摩和针可以改善HD患者的疲劳.
- 运动显示标准化平均差异 (SMD) 为-1.18 (95% CI -2.04至-0.31).
- 芳香疗法 (SMD -1.23,95% CI -1.96至 -0.50),按摩 (SMD -1.06,95% CI -1.47至 -0.65) 和针 (SMD -0.64,95% CI -1.03至 -0.25) 也表明对疲劳有潜在的益处.
结论:
- 运动,芳香疗法,按摩和针显示出对透析患者疲劳的潜在益处.
- 由于有限和异质的证据,药理学和其他非药理学干预措施的影响仍然不确定.
- 高质量,充足的未来研究对于澄清透析相关疲劳干预措施的有效性至关重要.
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