全癌症分析诊断后的运动和死亡率
Jessica A Lavery1, Paul C Boutros2,3,4,5, Jessica M Scott1,6
1Memorial Sloan Kettering Cancer Center, New York, NY.
概括
在癌症诊断后定期运动显著降低全因死亡率 (ACM) 和癌症死亡率. 益处因癌症类型而异,突出了癌症幸存者的个性化炼策略.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 公共卫生 公共卫生
背景情况:
- 诊断后身体活动对癌症幸存者的死亡结果的影响仍然不完全理解.
- 基于癌症类型的运动影响的变化需要进一步调查.
研究的目的:
- 研究癌症幸存者诊断后满足运动指南和因特定原因死亡率之间的关联.
- 为了确定运动对死亡率的影响是否在不同癌症部位上有所不同.
主要方法:
- 分析了来自前列腺,肺,结肠直肠和卵巢 (PLCO) 癌症查试验的11,480名癌症患者.
- 通过标准化调查量化诊断后的运动水平;使用Cox模型评估所有原因死亡率 (ACM),癌症死亡率和非癌症死亡率.
主要成果:
- 与指导方针一致的运动与ACM减少25% (HR,0.75) 以及癌症死亡率 (HR,0.79) 和其他原因死亡率 (HR,0.72) 的显著下降有关.
- 运动对死亡率的益处显示出剂量与反应的关系.
- 虽然在多个癌症部位观察到ACM的益处,但在头和脏癌症中特别注意到癌症死亡率降低.
结论:
- 坚持诊断后的运动指南为癌症幸存者提供了显著的全因死亡率好处,这是由于减少了癌症和非癌症死亡率.
- 运动对特定原因死亡率的具体影响取决于主要癌症部位.
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