仿生金属-化物剂可通过微波热动力疗法和免疫细胞激活实现协同作用的癌症治疗
Xiaomu Xu1,2,3, Qiong Wu2, Longfei Tan2
1Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 511436, China.
ACS applied materials & interfaces
|August 31, 2023
概括
这项研究引入了一种结合ZIF-67,MCOF3和向癌细胞膜的新型治疗剂,用于微波热动态疗法 (MTDT). 这种方法通过产生活性氧物种和免疫细胞激活来协同增强抗癌效应.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 癌症治疗 癌症治疗
背景情况:
- 微波热动态疗法 (MTDT) 通过结合热效应和活性氧物种 (ROS) 显示出癌症治疗的前景.
- 开发多功能药物对于局部癌症治疗至关重要,抑制复发和转移.
研究的目的:
- 开发一种基于ZIF-67的治疗药物,用于协同治疗局部癌症.
- 为了研究MTDT和免疫细胞激活对增强癌症消灭的联合作用.
主要方法:
- 使用ZIF-67,金属化物开放框架3 (MCOF3) 和热冲击蛋白70 (HSP70) 合成了一种多功能剂,具有癌细胞膜 (TCM) 外.
- 评估了该剂产生基基 (•OH) 的过氧化物样活性及其微波 (MW) 热敏感性.
- 评估了与MW辐射相结合的药物的体外和体内疗效,包括其对免疫细胞激活 (CD4 T细胞和CD8α T细胞) 的影响.
主要成果:
- 复合剂表现出类似过氧化物的活性,产生OH来破坏癌细胞.
- ZIF-67有效地将MW能量转化为热能,用于瘤的向加热.
- 持续的MW热疗促进了HSP70的表达,并激活了CD4和CD8αT细胞,从而产生了协同作用的抗癌效应.
- 该药物有效地抑制了瘤细胞在体外和体内生长.
结论:
- 开发的治疗药剂为有效的癌症消灭提供了一个有前途的策略.
- MTDT和免疫细胞激活的协同组合为癌症治疗提供了一种新的方法.
- 这项研究强调了仿生纳米载体在先进癌症治疗模式中的潜力.
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