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在性少数群体男性中使用兴奋剂,艾滋病病毒和免疫失调
Emily M Cherenack1, Jennifer V Chavez1, Claudia Martinez2
1Department of Public Health Sciences, University of Miami, 1120 NW 14th Street, Miami, FL 33136, United States.
Drug and alcohol dependence
|August 31, 2023
概括
性少数群体男性使用兴奋剂与免疫系统问题有关,无论艾滋病毒状况如何. 这项研究强调了药物使用对免疫激活和炎症的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 性少数群体男性 (SMM) 的兴奋剂使用率和艾滋病毒感染率很高.
- 刺激剂的使用加剧了免疫功能障碍,增加了艾滋病毒的感染和发病风险.
- 了解SMM与兴奋剂使用和艾滋病毒的免疫失调至关重要,特别是在COVID-19大流行期间.
研究的目的:
- 调查兴奋剂使用和艾滋病毒状况对SMM系统性免疫失调的独立和互动影响.
- 评估与兴奋剂使用和艾滋病毒感染有关的免疫激活和炎症标志物.
主要方法:
- 2020-2022年在佛罗里达州迈阿密对75名SMM进行的在线调查,评估艾滋病毒状况,病毒载量 (VL) 和兴奋剂使用.
- 测量可溶性血CD14 (sCD14) 和高灵敏性C反应蛋白 (hs-CRP) 作为免疫激活和炎症的标志物.
- 使用适度模型进行统计分析,以检查兴奋剂使用,艾滋病毒状况和免疫标志物之间的关联.
主要成果:
- 参与者包括30名艾滋病毒感染者 (PWH) 和45名HIV阴性SMM,在两组中都使用了大量的兴奋剂.
- 没有使用兴奋剂的HIV阴性SMM与使用兴奋剂的PWH相比,sCD14较低,hs-CRP升高的几率降低.
- 刺激剂的使用显示出与免疫失调的独立关联,即使在控制HIV状态和VL之后.
结论:
- 在SMM中使用兴奋剂独立地与增加的免疫激活和炎症有关.
- 研究结果强调了兴奋剂使用对性少数群体男性免疫健康的重大影响.
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