在调节创伤后应激障碍不同症状时,丘脑及其子区域的结构变化
Beining Yang1, Yulong Jia1, Weimin Zheng1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 100053 Beijing, China.
Psychiatry research. Neuroimaging
|August 31, 2023
概括
创伤后应激障碍 (PTSD) 与左丘脑灰质体积的减少有关. 胸膜变化,特别是在VLD和VLV亚区域,与PTSD症状严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 丘陵体对于感官处理至关重要,并与创伤后应激障碍 (PTSD) 的发展有关.
- 具体的胸膜变化及其与PTSD症状调节的相关性仍然不太清楚.
研究的目的:
- 调查PTSD患者和健康对照者 (HCs) 之间的丘脑及其子区域灰质量 (GMV) 差异.
- 探索体GMV和PTSD症状严重程度之间的关系.
- 评估作为创伤后应激障碍成像生物标志物的thalamic GMV变化的诊断潜力.
主要方法:
- 招募了14名PTSD患者和18名HC进行全脑T1加权3D磁化准备快速梯度回声成像扫描.
- 利用基于声素的形态测量 (VBM) 来估计在丘脑及其子区域的GMV.
- 执行了GMV和PTSD症状得分 (重新体验,唤醒,总CAPS) 和接收器操作特征 (ROC) 分析之间的相关性分析.
主要成果:
- 与HC相比,PTSD患者在左丘脑和子区域 (前部,中腰部,腹侧背部 (VLD),腹前部,腹侧腹部 (VLV)) 中显著减少了GMV.
- 在左侧VLD和VLV中的GMV与重新体验,唤醒症状和CAPS总分数之间发现了积极的相关性.
- 左VLV和VLD的组合GMV在PTSD分类的ROC分析中实现了0.813的曲线下的面积 (AUC).
结论:
- 这项研究揭示了PTSD患者的显著体GMV减少,特别是在特定的子区域.
- thalamic VLD和VLV GMV与PTSD症状严重程度有关,这表明它们在症状表现中的作用.
- thalamic GMV 变化可能作为潜在的神经成像标记物用于 PTSD 诊断和治疗向.
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