丁诺酸K-T,克莱罗丹二甲酸具有来自Tinospora crispa的抗炎活性
Yang-Li Zhu1, Li Deng1, Xin-Yan Dai1
1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
来自Tinospora crispa的十种新的克莱罗丹迪特尔类药物显示出抗神经炎症作用. 化合物3通过调节关键信号通路,显著抑制氧化和炎症标记物的产生.
科学领域:
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 丁诺斯波拉克里斯帕 (Tinospora crispa) 是一种生物活性化合物的植物来源.
- 克莱罗丹二甲酸是一种具有多种生物活性的自然产品.
- 神经炎症在各种神经疾病中起着至关重要的作用.
研究的目的:
- 从Tinospora crispa.中分离和描述新的克莱罗丹二甲类物质.
- 评估孤立化合物的抗神经炎症潜力.
- 为了阐明强大的抗神经炎症化合物的潜在作用机制.
主要方法:
- 使用光谱数据和X射线晶体学对化合物的隔离和结构阐明.
- 在体外测试以测量LPS激活的BV-2细胞中氧化 (NO) 的产生.
- 西部斑块,qRT-PCR和免疫光测试用于研究信号通路 (TLR4,Stat3,MAPK,HO-1).
主要成果:
- 分离了10种新的克莱罗丹二类 (丁类K-T,1-10) 和7种已知的化合物 (11-17).
- 化合物3和8显著抑制了NO生产,表现优于米诺环林.
- 化合物3有效抑制了iNOS,COX-2,TNF-α,IL-6和IL-1β的表达.
- 化合物3通过抑制TLR4/Stat3和MAPK通路并激活HO-1来抑制LPS诱导的神经炎症.
结论:
- 丁诺斯波拉克里斯帕 (Tinospora crispa) 是结构多样化的克莱罗丹二类植物的丰富来源.
- 化合物3通过多个信号通路表现出强大的抗神经炎症活性.
- 化合物3代表了神经炎症疾病的有希望的治疗候选者.
更多相关视频
14:18Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
Published on: October 13, 2023
08:49Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
