使用纳米粉预防甲状腺功能障碍的的生物调节.
Qinggele Borjihan1, Xuefang Liang2, Ting Chen1
1College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, PR China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, PR China.
Journal of hazardous materials
|August 31, 2023
概括
纳米粉颗粒有效地防止甲状腺细胞过量吸收,为诱导的甲状腺疾病提供了一种新的治疗策略. 这种方法调节了-胺共载体 (NIS) 蛋白质表达和代谢.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 内分泌学 在内分泌学.
背景情况:
- 在全球范围内,甲状腺疾病的发病率正在增加,通常与过度的摄入有关.
- 目前的细胞外干扰疗法旨在通过-化物共载体 (NIS) 阻止运输.
研究的目的:
- 研究纳米粉颗粒 (St NPs) 作为一种新型的细胞外干扰疗法,用于调节甲状腺吸收.
- 评估St NPs在防止甲状腺细胞过度吸收的疗效,在体外和体内.
主要方法:
- 利用纳米粉颗粒 (St NPs) 通过结合在葡萄糖α螺旋结构中封装.
- 向甲状腺细胞和斑马鱼施用StNP,以评估运输调节和代谢途径影响.
- 量化了化同载体 (NIS) 和自蛋白LC3B-II的表达水平.
主要成果:
- 细胞外的StNP成功地阻止了甲状腺细胞过量吸收.
- 降低了NIS蛋白 (0.06倍) 和自蛋白LC3B-II (0.35倍) 的表达.
- 证明St NPs调节斑马鱼中的代谢途径.
结论:
- 纳米粉颗粒代表了控制甲状腺吸收的新策略.
- 这种方法为预防和管理诱导的甲状腺疾病提供了新的方向.
- 该研究强调了在纳米医学中用于内分泌疾病管理的StNP的潜力.
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