相关实验视频

Updated: Jul 17, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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发现意义:RAD51调节器,BRCA2及其他变体分类的新视角

Hayley L Rein1, Kara A Bernstein2

  • 1University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.

DNA repair
|August 31, 2023
PubMed
概括

许多在同源重组 (HR) 基因中具有不确定的意义 (VUS) 变异的个体面临未知的癌症风险. 本综述探讨将VUS分类为关键的乳腺和卵巢癌基因,以更好地评估和治疗风险.

关键词:
这就是BRCA1的原因.这就是BRCA2的原因.乳腺癌 乳腺癌 乳腺癌同类的重组组合.同类的重组缺陷瘤.卵巢癌是发生在卵巢中的癌症.在PALB2中,PALB2是PALB2.在RAD51中使用RAD51.在RAD51C中,使用RAD51C.在RAD51D中,我们可以使用RAD51D.不知/不确定的意义的变体.

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